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Symbol
Name
ID

Fshr
follicle stimulating hormone receptor
MGI:95583

Phenotype annotations related to reproductive system

Darker colors indicate more annotations

Human Phenotypes	Streak ovary	Aplasia/hypoplasia of the uterus	Gonadal dysgenesis	Premature ovarian insufficiency	Primary amenorrhea	Secondary amenorrhea	Decreased fertility
Disease(s) Associated with FSHR	Streak ovary	Aplasia/hypoplasia of the uterus	Gonadal dysgenesis	Premature ovarian insufficiency	Primary amenorrhea	Secondary amenorrhea	Decreased fertility
46 XX gonadal dysgenesis
ovarian dysgenesis 1

Mouse Phenotypes

ovary hemorrhage

uterine hemorrhage

abnormal sperm flagellum morphology

abnormal sperm axoneme morphology

kinked sperm flagellum

abnormal female germ cell morphology

absent oocytes

oocyte degeneration

oligozoospermia

teratozoospermia

abnormal sperm head morphology

detached acrosome

abnormal sperm nucleus morphology

enlarged sperm head

abnormal male germ cell morphology

abnormal spermatid morphology

abnormal spermatogonia morphology

asthenozoospermia

increased granulosa cell proliferation

abnormal spermatogonia proliferation

decreased seminal vesicle weight

small seminal vesicle

abnormal endometrial gland morphology

enlarged endometrial glands

abnormal ovary morphology

absent corpus luteum

abnormal granulosa cell morphology

absent mature ovarian follicles

abnormal ovarian follicle number

decreased primary ovarian follicle number

absent ovarian follicles

abnormal ovarian folliculogenesis

impaired ovarian folliculogenesis

increased follicle recruitment

polyovular ovarian follicle

decreased ovary weight

small ovary

ovary atrophy

ovary cyst

abnormal seminiferous tubule morphology

abnormal seminiferous tubule epithelium morphology

decreased Sertoli cell number

small seminiferous tubules

abnormal testis development

abnormal testis size

decreased testis weight

small testis

increased ovary tumor incidence

increased ovarian carcinoma incidence

increased ovarian teratoma incidence

abnormal ovary physiology

decreased ovary secretion

abnormal testes secretion

uterus cyst

early reproductive senescence

increased uterus tumor incidence

enlarged clitoris

abnormal uterus morphology

myometrium hypoplasia

decreased uterus weight

increased uterus weight

enlarged uterus

small uterus

thin uterus

uterus atrophy

uterus adenomyosis

abnormal vagina epithelium morphology

abnormal vagina orifice morphology

vagina atresia

decreased vagina weight

vagina atrophy

abnormal spermatogenesis

abnormal spermiogenesis

abnormal epididymis morphology

abnormal caput epididymis morphology

small caput epididymis

abnormal corpus epididymis morphology

abnormal epididymis epithelium morphology

decreased epididymis weight

small epididymis

early vaginal opening

delayed female fertility

delayed male fertility

delayed sexual maturation

long gestation period

abnormal ovulation

anovulation

abnormal estrous cycle

prolonged diestrus

abnormal estrus

absent estrus

abnormal proestrus

absent estrous cycle

prolonged estrous cycle

abnormal uterine environment

female infertility

reduced female fertility

abnormal fertility/fecundity

decreased litter size

increased litter size

reduced male fertility

abnormal sperm physiology

Availability

Mouse Genotype

Fshr^tm1Hht/Fshr^tm1Hht

Fshr^tm1Mha/Fshr^tm1Mha

Fshr^tm1Saco/Fshr^tm1Saco

Fshr^tm1Hht/Fshr⁺

Fshr^tm1Saco/Fshr⁺

Tg(AMH-Fshr)27Hht/0

Tg(AMH-Fshr*D580H)#Hht/0

Tg(AMH-Fshr*D580Y)#Hht/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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